Background and objectives: Nepal has made progress with the control of HIV infection in recent SWORDS years.There have been changes in epidemiology, programme interventions in different population groups, and changes in policies over the last 10 years, particularly in diagnosis and treatment.Therefore, this review was conducted to identify the effe
Gain-of-function, focal segmental glomerulosclerosis Trpc6 mutation minimally affects susceptibility to renal injury in several mouse models
Mutations in TRPC6 are a cause of autosomal dominant focal segmental glomerulosclerosis in humans.Many of these mutations are known to have a gain-of-function effect on the non-specific cation channel function of TRPC6.In vitro studies have suggested these mutations affect several signaling pathways, but in vivo studies have largely compared wild-t
Effects of leuprolide acetate on the quality of life of patients with prostate cancer: A prospective longitudinal cohort study
Purpose: The aim of this study was to investigate the effect of androgen deprivation therapy (ADT) on the health-related quality of life (HRQOL) of patients with prostate cancer (PC) and compare the changes in the HRQOL between ADT alone and ADT plus intensity-modulated radiation therapy (IMRT).Materials and methods: Patients with PC were prospecti
Large-scale emulation of spatio-temporal variation in temperature under climate change
Future temperature variations under greenhouse gas (GHG) emission scenarios are critical to assess possible impacts on human society and make reasonable mitigation policies.Due to the huge running cost, Earth system models (ESMs) may be difficult to flexibly provide the temperature projections following some specific emission pathways for empirical